Gleason scores are a grading system for prostate cancer. Medical pathologists set Gleason scores after studying tissue samples under a microscope. Gleason scores range from 6 (low-grade cancer) to 10 (high-grade cancer). Low grade prostate cancer grows more slowly than high-grade cancer and is less likely to spread (metastasize).. The combination of Gleason scores into a 3-tier grouping (6,7,8-10) is used most frequently for prognostic and therapeutic purposes, despite 3+4=7 vs. 4+3=7 and 8 vs. 9-10 having very different prognoses. In practice the lowest score is now assigned a 6, although it is on a scale of 2-10. This leads to a logical yet incorrect assumption on the.

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Those two grades are then added to form the overall Gleason score (eg a 3 grade + a 4 grade = a 7 on the Gleason score). In theory, Gleason scores could range from 2 to 10, but pathologists today rarely give a score between 2 and 5 and are more likely to be in the range of 6 to 10 with 6 being the lowest grade of prostate cancer.. Gleason score: Clinical stage/rectal exam: Note: Abnormal 1 : Does not extend beyond prostate Abnormal. Gleason 3+3=6 and more than two cores; Clinical exam: Normal or half abnormality, one side only Management Options. These men have a very low risk of dying from prostate cancer and generally do well with most forms of therapy..