A review of medical records from 1997 to 2019 at Johns Hopkins Hospital yielded 186 individuals with a diagnosis of SPS. Clinical phenotypes were assigned by review of history and examination, and included classic SPS, stiff limb syndrome (symptoms limited to one extremity), SPS-plus (classic SPS with additional cerebellar and/or brainstem findings), pure cerebellar (without significant.. Stiff person syndrome is so rare that in the U.S., fewer than 5,000 living people have been diagnosed with it. It's a progressive autoimmune disorder that affects the central nervous system,.

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The Johns Hopkins Stiff Person Syndrome (SPS) Center, led by Dr. Scott Newsome, offers patient education, symptom management and hope for the future for people with this rare disorder. Our multi-specialty team includes experts in neurology, immunology, ophthalmology, neuromuscular disease and.. Stiff person syndrome (SPS) is a rare disorder of the central nervous system characterized by rigidity and stimulus triggered painful muscle spasms of predominantly axial and proximal limb muscles. It was first described in 1956 by Frederick Moersch and Henry Woltman based on a case series of 14 patients with progressive fluctuating tightness of the spinal, abdominal, and thigh muscles.